Experimental evaluation of effects of a pyrimidine derivative 4CPTP on cardiovascular system

Design, synthesis and anticancer evaluation of novel thiazine, pyrimidine and pyridine derivatives

Acylisothiocyanate (1) was allowed to react with benzylidene malononitrile producing oxazine derivative (2). Also, compound (1) was reacted with sodium azide followed by refluxing with sodium ethoxide affording thiazinotetrazole derivative (4). The reaction of acetylacetone with compound (1) gave pyridine derivative (5) by intramolecular cycloaddition while it was reacted with N-methyl aniline ...

Synthesis, Radioiodination and Biodistribution Evaluation of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxybenzofuran-6-ol

This study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (SPBF) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. These benzofuran derivatives may be useful amyloid imaging agents for detecting B-amyloid plagues in the brain of Alzheimer’s disease. The precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...

Evaluation of the effects of Zataria multiflora, Geranium pelargonium, Myrth and Lemon essences on immune system function in experimental animals

Evaluation of GABA Receptors of Ventral Tegmental Area in Cardiovascular Responses in Rat

Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...

Effects of Benzimidazole derivatives on digestive system and cardiovascular system

One of the goals of medicinal chemistry research and drug discovery is to provide a rationalbasis for the design of new medicinal agents. Organic compounds and their reactions have beenutilized by people since antiquity. Due to the increasing demand for bioactive molecules, organicchemists are increasingly required to synthesize new compounds of biological interest. AsBenzimidazoles are very us...